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Interferon Alpha-2: Pre-Clinical and Clinical Evaluation

Interferon Alpha-2: Pre-Clinical and Clinical Evaluation ebook ISBN: 146132579X
Publisher: Springer Science & Business Media
Author: Daniel L. Kisner,J.F. Smyth
Number of Pages: 112 
File: interferon-alpha-2-pre-clinical-and-clinical-evaluation.pdf
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Interferon alpha-2 is a genetically engineered, highly purified pharmaceutical agent that has undergone extensive phase I and phase II clinical study in more than 1000 patients. The material has biological activity by intravenous, intramus cular and subcutaneous routes. Clinical toxicity principally involves the 'influen za like' syndrome previously seen with native interferons. Other important toxi cities include anorexia, hepatitis, confusion and myelosuppression. Tolerable doses in multiple schedules and routes of administration have been determined. Phase II clinical trials with multiple routes and schedules of administration have been performed. Significant clinical activity has been found in non Hodgkin's lymphomas (both low grade and high grade), refractory and relapsing multiple myeloma, hairy cell leukemia, Kaposi's sarcoma, with suggestions of activity in Hodgkin's disease, renal cell carcinoma, and melanoma. The studies performed to date have for the most part involved small numbers of heavily pre-treated patients. Large-scale clinical trials in some of these disea ses are now warranted in populations of patients with as little bulk disease and prior treatment as is feasible for each tumour type. This is particularly the case in . Hodgkin's disease and subcategories of the non-Hodgkin's lymphomas. Alterna tely, interferon alpha-2 might be used to maintain remissions induced by other modalities (i. e. , in NHL, multiple myeloma, ovarian cancer). In some advanced disease settings, combinations of interferon alpha-2 with chemotherapeutic agents should now be investigated.

Drawn To The Alpha 2

Drawn To The Alpha 2 ebook ISBN:
Publisher: Mahogany Publications
Author: Willow Brooks
Number of Pages: 250 
File: drawn-to-the-alpha-2.pdf
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When Sophia and Van travel to a perilous forest in Romania, where packs of werewolves and hideously ugly vampires rule the twilight hours, they discover that Sophia is much more than a beautiful woman who has fallen hard for a loner with a secret. She's "The Mother", a mortal woman with the power to save all werewolves from the darkness that haunts their hearts. But first she must prove herself worthy of the title. It soon becomes clear that the task she is assigned with might also be the death of her... Find out what happens in part two of Drawn To The Alpha! keywords: bbw werewolf romance, bbw shifter romance free, paranormal romance bbw shapeshifter, bbw shifter, werewolf romance, werewolf,paranormal paranormal romance,bbw shapeshifter romance, bbw romance, bbw erotical free books, BBW Shapeshifter Romance, Vampire romance, Paranormal Romance, Steamy Romance, Romance with Sex, paranormal romance free, paranormal books free, Free romance, free shifter, free paranormal romance, free urban fantasy, Free bbw, free, free paranormal romance books for adults, free bbw romance novels for adults, Shifter romance, shape shifter romance, new adult, mystery, paranormal, supernatural, fantasy, folklore, folktale, folk tale, legend, legends, myth, myths, action adventure, werewolf romance, Psychic, Witch, Ghost, Werewolf, Urban Fantasy, Suspense, Thriller, Supernatural, Free ebook

The alpha-2 Adrenergic Receptors

The alpha-2 Adrenergic Receptors ebook ISBN: 1461245966
Publisher: Springer Science & Business Media
Author: Lee E. Limbird
Number of Pages: 368 
File: the-alpha-2-adrenergic-receptors.pdf
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Locke & Key: Alpha #2

Locke & Key: Alpha #2 ebook ISBN:
Publisher: IDW Publishing
Author: Joe Hill
Number of Pages: N.A 
File: locke-key-alpha-2.pdf
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'The End.'' A door claps softly shut. A key scrapes in a last rusted lock. It ends here: the story of the Locke children and their desperate, tragic battle with the monster set on destroying them... the past. Join Gabriel Rodriguez and Joe Hill for the final chapter of Locke & Key.

ETUDE DES SYSTEMES DE TRANSDUCTION ALPHA-2 ADRENERGIQUES CONTROLANT LA POTENTIALISATION ET L'INHIBITION DE LA PRODUCTION D'AMPC DANS LE MYOMETRE GRAVIDE. ANALYSE EXPERIMENTALE SUR LES CELLULES DDT 1 MF-2

ETUDE DES SYSTEMES DE TRANSDUCTION ALPHA-2 ADRENERGIQUES CONTROLANT LA POTENTIALISATION ET L'INHIBITION DE LA PRODUCTION D'AMPC DANS LE MYOMETRE GRAVIDE. ANALYSE EXPERIMENTALE SUR LES CELLULES DDT 1 MF-2 ebook ISBN:
Publisher:
Author: RACHEL.. BOUET ALARD
Number of Pages: 195 
File: etude-des-systemes-de-transduction-alpha-2-adrenergiques-controlant-la-potentialisation-et-l-inhibition-de-la-production-d-ampc-dans-le-myometre-gravide-analyse-experimentale-sur-les-cellules-ddt-1-mf-2.pdf
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DANS LE MYOMETRE DE RATTE GRAVIDE, LES RECEPTEURS ALPHA-2 ADRENERGIQUES (R ALPHA-2 AD) MODULENT LE SYSTEME ADENYLATE CYCLASIQUE STIMULE PAR LA VOIE BETA-2 ADRENERGIQUE DE MANIERE DIFFERENTIELLE EN FONCTION DU STADE DE LA GESTATION : POTENTIALISATION A MI-GESTATION, INHIBITION A TERME. CES DEUX EFFETS IMPLIQUENT LES PROTEINES GI2-3. DANS LE BUT D'ANALYSER LES MECANISMES MOLECULAIRES RESPONSABLES DE LA VERSATILITE DE CE SYSTEME, NOUS AVONS CARACTERISE : 1) LA NATURE DES SOUS-TYPES DE R ALPHA-2 AD ET LA VARIATION DE LEUR EXPRESSION AU COURS DE LA GESTATION, 2) LES ISOFORMES DE L'ADENYLATE CYCLASE (AC). LES RESULTATS OBTENUS A PARTIR D'ETUDES PHARMACOLOGIQUES ET DE NORTHERN BLOTTING INDIQUENT QUE LES SOUS-TYPES A ET B DES R ALPHA-2 AD SONT EXPRIMES. LE SOUS-TYPE A PREDOMINE A MI-GESTATION ALORS QUE LE SOUS-TYPE B AUGMENTE A TERME. CONCERNANT LES AC, NOUS AVONS IDENTIFIE LES TRANSCRITS DES ISOFORMES II-VII ET IX. L'EFFET POTENTIALISATEUR OBSERVE A MI-GESTATION MET EN JEU LES DIMERES GI BETA GAMMA ET LES ACII, IV ET/OU VII. A TERME, LA DISPARITION DE L'EFFET POTENTIALISATEUR DU SYSTEME CYCLASIQUE ASSOCIEE A L'AUGMENTATION DU SOUS-TYPE B, SUGGERE UN ROLE REGULATEUR DIFFERENTIEL DES DEUX SOUS-TYPES DE R ALPHA-2 AD. DANS LES CELLULES DDT, MF-2 NOUS AVONS SUREXPRIME PAR TRANSFECTION LE SOUS-TYPE A OU B DES R ALPHA-2 AD ET L'ACII. NOUS AVONS MONTRE DANS CE MODELE 1/ QUE LES DEUX SOUS-TYPES ACTIVES PAR L'ADRENALINE SONT CAPABLES DE POTENTIALISER L'AC II STIMULEE PAR LA VOIE BETA-2 AD, 2/ QUE L'ACTIVATION DU SOUS-TYPE B PAR LA CLONIDINE INDUIT UN EFFET INHIBITEUR SUR LE SYSTEME CYCLASIQUE. DES ETUDES DE COUPLAGE REVELENT QUE L'EFFET POTENTIALISATEUR DE L'AC II EST ASSOCIE AU RECRUTEMENT DES PROTEINES GI2 ET GI3 PAR LES DEUX SOUS-TYPES DE R ALPHA-2 AD ALORS QUE L'EFFET INHIBITEUR SEMBLE N'IMPLIQUER QUE L'ACTIVATION DE LA PROTEINE GI2 PAR LE SOUS-TYPE B. L'INTEGRATION DE CES DONNEES EXPERIMENTALES DANS LE MODELE PHYSIOLOGIQUE DU MYOMETRE, EST PROPOSEE DANS NOTRE CONCLUSION GENERALE.

Alpha-Globulins—Advances in Research and Application: 2013 Edition

Alpha-Globulins—Advances in Research and Application: 2013 Edition ebook ISBN: 1481684728
Publisher: ScholarlyEditions
Author: N.A
Number of Pages: 92 
File: alpha-globulins-advances-in-research-and-application-2013-edition.pdf
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Alpha-Globulins—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Ceruloplasmin in a concise format. The editors have built Alpha-Globulins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Ceruloplasmin in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Alpha-Globulins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Cells: Advances in Research and Application: 2011 Edition

Cells: Advances in Research and Application: 2011 Edition ebook ISBN: 1464920605
Publisher: ScholarlyEditions
Author: N.A
Number of Pages: 2791 
File: cells-advances-in-research-and-application-2011-edition.pdf
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Cells: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cells. The editors have built Cells: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cells in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cells: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Cytokines—Advances in Research and Application: 2013 Edition

Cytokines—Advances in Research and Application: 2013 Edition ebook ISBN: 1481699199
Publisher: ScholarlyEditions
Author: N.A
Number of Pages: 680 
File: cytokines-advances-in-research-and-application-2013-edition.pdf
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Cytokines—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Osteopontin. The editors have built Cytokines—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Osteopontin in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cytokines—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

High Enthalpy Gas Dynamics

High Enthalpy Gas Dynamics ebook ISBN: 1118821912
Publisher: John Wiley & Sons
Author: Ethirajan Rathakrishnan
Number of Pages: 352 
File: high-enthalpy-gas-dynamics.pdf
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This is an introductory level textbook which explains the elements of high temperature and high-speed gas dynamics. written in a clear and easy to follow style, the author covers all the latest developments in the field including basic thermodynamic principles, compressible flow regimes and waves propagation in one volume covers theoretical modeling of High Enthalpy Flows, with particular focus on problems in internal and external gas-dynamic flows, of interest in the fields of rockets propulsion and hypersonic aerodynamics High enthalpy gas dynamics is a compulsory course for aerospace engineering students and this book is a result of over 25 years' teaching by the author accompanying website includes a Solutions Manual for exercises listed at the end of each chapter, plus lecture slides

Multiple Myeloma and Related Serum Protein Disorders

Multiple Myeloma and Related Serum Protein Disorders ebook ISBN: 1617050156
Publisher: Demos Medical Publishing
Author: Neil S. Harris, MD,William E. Winter
Number of Pages: 164 
File: multiple-myeloma-and-related-serum-protein-disorders.pdf
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Multiple Myeloma and Related Serum Protein Disorders is a practical guide to the clinical use of serum and urine electrophoresis and also includes coverage of immunofixation electrophoresis. These techniques are essential in the accurate identification of monoclonal gammopathies and the diagnosis of multiple myeloma and related disorders. Interpretation is often challenging even for the experienced practitioner. Throughout the book the emphasis is on indications and practical aspects of interpreting test results. Particular attention is paid to differentiating false negative and false positive test results. The text provides clear, practical discussions extensively supported by representative images to guide the reader to accurate identification of specimens. Multiple Myeloma and Related Serum Protein Disorders serves as a practical guide for clinical pathologists as well as pathology residents, clinical laboratory scientists and medical technologists. Multiple Myeloma and Related Serum Protein Disorders Features Include: Covers both serum (blood) and urine electrophoresis Covers immunofixation electrophoresis Particular attention to differentiating false negative and false positive reports Well-illustrated throughout Concise, practical guide for practitioners and residents

Laboratory Tests and Diagnostic Procedures - E-Book

Laboratory Tests and Diagnostic Procedures - E-Book ebook ISBN: 1455745022
Publisher: Elsevier Health Sciences
Author: Cynthia C. Chernecky,Barbara J. Berger
Number of Pages: 1232 
File: laboratory-tests-and-diagnostic-procedures-e-book.pdf
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Find complete answers to questions such as which laboratory tests to order or what the results might mean. Laboratory Tests and Diagnostic Procedures, 6th Edition covers more tests than any other reference of its kind, with over 900 lab tests and diagnostic procedures in all. In Part I, you'll find an alphabetical list of hundreds of diseases, conditions, and symptoms, including the tests and procedures most commonly used to confirm or rule out a suspected diagnosis. In Part II, you’ll find descriptions of virtually every laboratory and diagnostic test available. This edition is updated with the latest research and over 20 NEW test entries. Written by educator Cynthia Chernecky and clinical nurse specialist Barbara Berger, this lab reference covers today’s lab tests with concise, easy-to-use information. More than 900 laboratory tests and diagnostic procedures are included — more than any other reference! Over 600 diseases, conditions, and symptoms are listed, along with the tests used to confirm them. Alphabetical organization and A-to-Z thumb tabs make it easy to find the information you’re looking for. Alternative test names and acronyms are cross-referenced to simplify lookup. Instructions for client and family teaching help you offer guidance concerning test preparation and follow-up care. Age and gender-specific norms are provided, giving you complete lifespan coverage. Risks and Contraindications are highlighted to help you safeguard your patients and provide effective care. Panic Level Symptoms and Treatment are provided for dangerously increased and decreased levels. Minimum volumes for blood samples are included, useful when a client’s blood preservation is essential, as well as information on whether blood specimens can be drawn during hemodialysis. Tests for toxic substances are included, making this a lab, diagnostic, and toxicology book all in one. Abbreviations, measurement prefixes, and symbols are listed on the front and back covers for convenience. Information on herbal supplements indicates when a client’s use of natural remedies might affect test results. Over 20 NEW test entries present the latest tests and procedures, with a strong focus on affordable, clinically relevant genetic tests. UPDATED content includes the latest research relating to accuracy of tests, diagnostic value of results, and associated cost-benefit ratios.

Protein Classification

Protein Classification ebook ISBN: 9781230834672
Publisher: University-Press.org
Author: Source Wikipedia
Number of Pages: 110 
File: protein-classification.pdf
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Pages: 42. Chapters: Alpha-2-Macroglobulin-like 1, CATH, Families of structurally similar proteins, InterPro, List of MeSH codes (D12.776), List of MeSH codes (D12.776.124), List of proteins, List of types of proteins, Protein family, Protein subfamily, Simple Modular Architecture Research Tool, Structural Classification of Proteins database, SUPERFAMILY. Excerpt: This is part of the list of the "D" codes for MeSH. It is a product of the United States National Library of Medicine. Source for content is here. (File "2006 MeSH Trees.") (no MeSHNumber) LAPP (leech anti-platelet protein) - presently redirects to LAMP (software bundle) where the term is not mentioned This is a sub-part (blood proteins only) of List of MeSH codes (D12.776), itself a part of the list of the "D" codes for MeSH. It is a product of the United States National Library of Medicine. Source for content is here. (File "2006 MeSH Trees.") This list of proteins is part of on-going attempts to manage the large amounts of information concerning genes and proteins. Gene sequencing efforts and genome sequencing projects have led to the creation of many gene databases and attempts to organize all of the available information. Classifications may be based on structure as in CATH and SCOP. The List of types of proteins (on this page, below) is based on the biological categories described in the GO Slims list for "GOA and whole proteome analysis" (format-version: 1.0 date: 17:08:2005 14:57). Modifications are being made as needed, but an effort is being made to keep these "top level" categories limited in number. Note: the original GOA and whole proteome analysis slim contains many suggested "synonyms" and subcategories for the following categories.Note: There is also a List of proteins. Specific proteins may be listed there. This page (see below) is for descriptions of...

Issues in General Science and Scientific Theory and Method: 2011 Edition

Issues in General Science and Scientific Theory and Method: 2011 Edition ebook ISBN: 1464963479
Publisher: ScholarlyEditions
Author: N.A
Number of Pages: 3278 
File: issues-in-general-science-and-scientific-theory-and-method-2011-edition.pdf
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Issues in General Science and Scientific Theory and Method: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about General Science and Scientific Theory and Method. The editors have built Issues in General Science and Scientific Theory and Method: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about General Science and Scientific Theory and Method in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in General Science and Scientific Theory and Method: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Adrenergic alpha Receptors—Advances in Research and Application: 2012 Edition

Adrenergic alpha Receptors—Advances in Research and Application: 2012 Edition ebook ISBN: 1481632663
Publisher: ScholarlyEditions
Author: N.A
Number of Pages: 23 
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Adrenergic alpha Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Adrenergic alpha Receptors in a compact format. The editors have built Adrenergic alpha Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Adrenergic alpha Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Adrenergic alpha Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Serpins—Advances in Research and Application: 2012 Edition

Serpins—Advances in Research and Application: 2012 Edition ebook ISBN: 148160158X
Publisher: ScholarlyEditions
Author: N.A
Number of Pages: 134 
File: serpins-advances-in-research-and-application-2012-edition.pdf
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Serpins—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Serpins. The editors have built Serpins—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Serpins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Serpins—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.